FOX · Running

Best Medicine

Drama, Comedy, Medical · 2026 · Rated 6.2/10

Next: S2 E3, Crate Expectations · 2026-10-06

In Best Medicine a brilliant surgeon leaves Boston to become a small-town doctor where he spent childhood summers. Despite his medical skills, his rude manner alienates locals as he battles hidden phobias and struggles with personal connections.

Cast

Josh Charles Dr. Martin Best

Abigail Spencer Louisa Gavin

Josh Segarra Sheriff Mark Mylow

Annie Potts Aunt Sarah

Cree Elaine Denton

Stephen Spinella Greg Garrison

Jason Veasey George Brady

Season 2

Season 1 Season 2

E1 Be Careful What You Fish For 2026-09-20 · 70 min While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.

E2 Breakin' in Is Hard to Do 2026-09-29 · 60 min When the Port Wenn pharmacy is robbed, including Louisa's critical time-sensitive medicine, Martin deduces that the culprit desperately needs his help. Meanwhile, Greg and George clash with a rival food truck owner, Sarah tries to bond with Eden, and Martin is on the receiving end of a special brand of Port Wenn affection.

E3 Crate Expectations 2026-10-06 · 60 min As the citizens of Port Wenn get competitive during their annual floating crate race, Martin urgently tries to give important medical advice when three men have positive pregnancy tests. Meanwhile, Eden learns she wants to be liked after her singing 'causes' a man to pass out and former record-holder Sarah coaches Peter in the art of crate racing.

E4 No Place Like Om 2026-10-13 · 60 min As Martin desperately tries to leave Port Wenn to meet Eden in Boston for the weekend, he must first investigate the extremely strange behavior of three patients who have all recently visited a meditation retreat; Mark is affected by the high school's graduation; Sarah's first guest in her rented spare room is none other than ex-paramour Eddie McCroy.

E5 TBA 2026-10-20 · 60 min

E6 TBA 2026-11-03 · 60 min

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